It’s March in South Florida. The beach towns are flush with young people looking for action and excitement. For one unlucky group of thrill-seeking spring breakers, their adventure leads to the black waters of the Florida Everglades – a place with mosquitoes the size of birds, snakes as long as school buses and tens of thousands of flesh-ripping alligators. But beyond the scope of the traditional predators famous for keeping the glades wild is another phenomenon – one with two legs and an insatiable thirst for killing.
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Famous organist Anton Phibes is horribly disfigured in an automobile accident while rushing to the side of his sick wife and presumed to be dead. Once Phibes learns that his wife died on the operating table, he is convinced the doctor’s are responsible and begins exacting his revenge on all those involved.
Andy and Thelma, an urbanite couple living in Madrid, leave their apartment for a pleasant day around the city with their dog. They cross paths with Bruno and Anne, a strange couple who invite them to their foreboding country estate. A storm hits that evening and the two stay overnight. The couples engage in a bit of harmless communication with spirits via ouija board, but soon past conflicts arise Thelma had an affair with Andy’s brother, and Anne criticizes Bruno over his attempted suicide. This is only the beginning of all the horrors that will haunts them in the house.